Research at Bone & Joint Institute

Advancing Scientifically Proven Care

Breaking Ground in Muskuloskeletal Research 

‘Best-in-Class’ Outcomes Backed by Data and Analysis

A Multidisciplinary Team of Providers and Researchers 

Our Mission

The Bone & Joint Institute at Hartford Hospital is a multidisciplinary group of providers united by the common goal to deliver world class comprehensive musculoskeletal care. In order to achieve this level of ‘best-in-class’ quality outcomes, it is necessary to provide care which is evidence based. This places the collection and analysis of valid and reliable data at the epicenter of the Institute and with it the support for critical thinking, research, education, and innovation. The data and the critical analysis thereof will enable scientifically proven care while simultaneously striving to investigate ways to improve the musculoskeletal health and wellbeing of all individuals locally and around the globe.

Our Team

Carl W. Nissen, MD

Medical Advisor for Research

Dr. Nissen is a Clinical Professor of Orthopedic Surgery at the University of Connecticut and has worked extensively with orthopedic residents and sports medicine fellows throughout his career twice earning Educator of the Year for his efforts.

Meet Dr. Nissen

Clinical Research Coordinator

• David Fraello

Supervisor, Clinical Trial Unit Leader

• Bethany A. Samperi, CCRP

Senior Scientists

• Regina O. Kostyun, MSEd, ATC
• Matthew J. Solomito, MS, PhD
• Sara E. Strecker, MS, PhD

Research Assistant

• Monika Kozyra, MD


Director, Analytics

• Nischala Tolat, MS, MBA, SSBBP, NSLS

Data Manager, Healthcare Informatics

• Angie Rivera
• Carlo Ronca, BS Management Information System

Systems Analyst, RTLS

• Eddie Rivera, BS Management Information System
• Sean Backstrom, BS Information Technology

Recent Publications and Presentations

2022 Publications

Connors, J. P., Lindsay, A. D., & Witmer, D. K. (2022). Cephalomedullary Nail as a Definitive Antibiotic Spacer for Multidrug Resistant Periprosthetic Infection of a Proximal Femoral Endoprosthesis. Techniques in Orthopaedics.

Geiselmann, M. T., Goldberg, L. K., Strecker, S. E., & Witmer, D. K. (2022). Does the Use of an Intra-Articular Local Anesthetic Injection During Total Hip Arthroplasty Reduce Patient Reported Pain Scores or Patient Opioid Consumption? The Journal of Arthroplasty37(4), 748–754.

Howard, E. E., Margolis, L. M., Fussell, M. A., Rios, C. G., Meisterling, E. M., Lena, C. J., Pasiakos, S. M., & Rodriguez, N. R. (2022). Effect of High-Protein Diets on Integrated Myofibrillar Protein Synthesis before Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Pilot Study. Nutrients14(3).

Magaldi, R. J., Strecker, S. E., Nissen, C. W., Carangelo, R. J., & Grady-Benson, J. (2022). Preoperative Factors to Assess Risk for Postoperative Urinary Retention in Total Joint Arthroplasty: A Retrospective Analysis. Arthroplasty Today13, 181–187.

Nissen, C. W., Albright, J. C., Anderson, C. N., Busch, M. T., Carlson, C., Carsen, S., Chambers, H. G., Edmonds, E. W., Ellermann, J. M., Ellis, H. B., Jr, Erickson, J. B., Fabricant, P. D., Ganley, T. J., Green, D. W., Grimm, N. L., Heyworth, B. E., Po, J. H. H., Kocher, M. S., Kostyun, R. O., … ROCK Group. (2022). Descriptive Epidemiology From the Research in Osteochondritis Dissecans of the Knee (ROCK) Prospective Cohort. The American Journal of Sports Medicine50(1), 118–127.

Witmer, D., Solomito, M. J., Kumar, M., Shearier, E., & Davis, S. (2022). Efficacy and Safety of Locally Injected Tranexamic Acid in Hip Fracture Patients: A Retrospective Review. Journal of Orthopaedic Trauma36(3), 147–151.

2021 Publications

Chizuk, H. M., Haider, M. N., Solomito, M., Kostyun, R., Willer, B. S., Leddy, J. J., & Wang, D. (2021). Concussion reporting behaviors in student athletes across sexes and levels of contact. Journal of Concussion5, 20597002211015093.

Kahan, J. B., Schneble, C. A., Applonie, R., Nicholson, A., Whittall, I., Talley-Bruns, R., Jorgensen, A., LaVette, N., Moran, J., Ware, J. K., Lee, F. Y., & Blaine, T. A. (2021). Early success of the arthroscopic-assisted locked loop suprapectoral biceps tenodesis. JSES Reviews, Reports, and Techniques1(2), 96–101.

Kia, C., & Esmende, S. (2021). Robotic-assisted Spine Surgery: A Review of its Development, Outcomes, and Economics on Practice. Techniques in Orthopaedics36(3), 272.

McGrath, M., Spira, B., Grady-Benson, J., Bruning, P., Kress, K., Belniak, R., Golladay, G. J., & Damodar, D. (2021). The Impact of the COVID-19 Pandemic on PhysiciansPerception of Digital Health in Orthopedics. Journal of Orthopedic Experience & Innovation, 3.

Solomito, M. J., Garibay, E. J., Golan, E., & Nissen, C. W. (2021). Elbow flexion post ball release is associated with the elbow varus deceleration moments in baseball pitching. Sports Biomechanics / International Society of Biomechanics in Sports20(3), 370–379.

Tomasevich, K. M., Moradi, S., & Lindsay, A. D. (2021). Chondrosarcoma Arising in Synovial Chondromatosis of the Hip. In JBJS Case Connector, 11(3).


Regina Kostyun, Sara E. Strecker, John Magaldi. The Prevalence of Multisystem Diagnoses Among Patients with Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder: A Retrospective Analysis Using a Large Healthcare Claims Database.  Presented at: 2022 International Scientific Symposium on the Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders; Sept 14-18, 2022; Rome, Italy.

Sara E. Strecker, John Magaldi. Ehlers-Danlos: Physician Perspectives in Ehlers-Danlos. Presented at: 2022 International Scientific Symposium on the Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders; Sept 14-18, 2022; Rome, Italy.

Jesse Eisler, Matthew Solomito. Determining the Utility of the RAPSF Score as a Means of Predicting Post-Surgical Outcomes Following Elective Lumbar Fusions. Presented at: LSRS-April 2022; Chicago, IL.

Sean Esmende, Matthew Solomito, Jesse Eisler, Kevin Finkel, Pranjali Kainkaryam, Carla Maffeo-Mitchell. Utility of the Transversus Abdominis Plane and Rectus Sheath Blocks in Patients Undergoing Anterior Lumbar Interbody Fusion. Presented at: LSRS; April 2022; Chicago, IL.

Heeren Makanji, Matthew Solomito, Sean Esmende, Carla Maffeo-Mitchell, Kevin Finkel. Utility of the Erector Spinae Plane Block in Posterior and Transforaminal Lumbar Interbody Fusions. Presented at: LSRS; April 2022; Chicago, IL.

Mandeep Kumar, Regina Kostyun, Gilbert Agyeman, Connor Seeley, Ilene Staff. Fever is a Common and Largely Benign Finding in Patients Undergoing Total Joint Arthroplasty (TJA): A Retrospective Analysis of 3939 Patients. Presented at: 17th Annual Perioperative Medicine Summit; March 4-6, 2022; San Diego, CA.

Iva Brinley, Elizabeth Briglia, Donna Jones, Mikaela Dunn, Jenna Ouellette, Makaila Sinclair, Erica Braudrick, Regina Kostyun, Sherry Stohler. Knowledge, Attitudes, and Beliefs Toward Early Mobilization for Orthopaedic Patients: A Descriptive Survey of an Intra-Professional Team. Presented at: CT Nursing Research Alliance; October 22, 2021; Hartford, CT.

Leah Goldberg, Daniel K. Witmer, Sara E. Strecker. Does the Use of an Intraoperative Local Anesthetic Injection During Primary Total Hip Arthroplasty Reduce Postoperative Opioid Use or Patient Reported Pain Scores? Presented at: CT Nursing Research Alliance; October 22, 2021; Hartford, CT.

Erica Braudrick, Sara E. Strecker, William Nolan. Multimodal Analgesia is Superior to Opiates Alone After Tibial Fracture in Patients with Substance Abuse History. Presented at: National Association of Orthopedic Nurses (NAON); May 22-25, 2021; Palm Springs, CA.

The ROCK Group. A Descriptive Epidemiology of Our First 1000 Patients. Presented at: POSNA Annual Meeting; May 12-15, 2021; Dallas, TX.

Robert J. Carangelo, Robert J. Magaldi, Sara E. Strecker, Tracy Gonzalez, Daniel Beaupre. High Pre-Operative Post Void Residual Volume May Predict Straight Catheterization Following Total Hop Arthroplasty. Presented at: American Academy of Orthopedic Surgeons (AAOS); March 9-13, 2021; San Diego, CA


Upcoming Research Opportunities

Anterior Cruciate Ligament (ACL) Research Study

A Prospective, Randomized Clinical Trial Evaluating the Effect of Bone Grafting on Post-Operative Anterior Knee Pain in Patients Undergoing ACL Reconstruction with a Bone-Patella Tendon-Bone Autograft.

Drs. Cliff Rios, Kristopher Ware, and Carl Nissen are conducting a study to examine whether filling in the graft donor sites with your own bone chips (bone grafting) will improve your outcome.

Eligibility Criteria

  • Patients 18 years of age and older
  • Patients undergoing a bone-patella tendon-bone ACL reconstruction surgery
  • Willing to participate in the study and be randomized into study groups
  • Provide information on your injury and recovery during four office visits with your surgeon

Please contact the Bone and Joint Research Department at for more information.

Research at Bone & Joint Institute





Hartford Hospital

Bone & Joint Institute

The Bone & Joint Institute at Hartford Hospital is a multidisciplinary group of providers united by the common goal to deliver world class comprehensive musculoskeletal care.

About Bone & Joint Institute