Research at Bone & Joint Institute

Advancing Scientifically Proven Care

Breaking Ground in Muskuloskeletal Research 

‘Best-in-Class’ Outcomes Backed by Data and Analysis

A Multidisciplinary Team of Providers and Researchers 

Our Mission

The Bone & Joint Institute at Hartford Hospital is a multidisciplinary group of providers united by the common goal to deliver world class comprehensive musculoskeletal care. In order to achieve this level of ‘best-in-class’ quality outcomes, it is necessary to provide care which is evidence based. This places the collection and analysis of valid and reliable data at the epicenter of the Institute and with it the support for critical thinking, research, education, and innovation. The data and the critical analysis thereof will enable scientifically proven care while simultaneously striving to investigate ways to improve the musculoskeletal health and wellbeing of all individuals locally and around the globe.

Our Team

Carl W. Nissen, M.D.

Medical Advisor for Research

Dr. Nissen is a Clinical Professor of Orthopedic Surgery at the University of Connecticut and has worked extensively with orthopedic residents and sports medicine fellows throughout his career twice earning Educator of the Year for his efforts.

Meet Dr. Nissen

Clinical Research Coordinators

• Emily R. Shearier, PhD

Clinical Trial Unit Leader, Supervisor

• Bethany A. Samperi, CCRP

Manager Informatics, Data Analytics, and BI

• Nischala Tolat, MBA, MS, SSBBP

Research Assistants

• Rashi Dua, BA
• Oisharya Dasgupta

Healthcare Informatics, Data Manager

• Angie Rivera

Senior Scientists

• Regina O. Kostyun, MSEd, ATC
• Matthew J. Solomito, MS, PhD
• Sara E. Strecker, MS, PhD

Recent Publications 2019-20

Aseltine, R. H., Wang, W., Benthien, R. A., Katz, M., Wagner, C., Yan, J., & Lewis, C. G. (2019). Reductions in Race and Ethnic Disparities in Hospital Readmissions Following Total Joint Arthroplasty from 2005 to 2015. The Journal of Bone and Joint Surgery, 101(22), 2044–2050.


Bellas, N., Stohler, S., Staff, I., Majk, K., Lewis, C., Davis, S., & Kumar, M. (2020). Impact of Preoperative Specialty Consults on Hospitalist Comanagement of Hip Fracture Patients. Journal of Hospital Medicine, 15(1), 16–21.


Blaine, T. A., Wiseman, S. P., Kovacevic, D., & Morrey, B. F. (2019). Interposition Arthroplasty for Posttraumatic Ulnohumeral Arthritis. Journal of Shoulder and Elbow Arthroplasty, 3, 247154921983639.


Campbell, R. S., Lehr, M. E., Livingston, A., McCurdy, M., & Ware, J. K. (2019). Intrinsic modifiable risk factors in ballet dancers: Applying evidence based practice principles to enhance clinical applications. Physical Therapy in Sport, 38(2019), 106–114.


Kethireddy, N., & Vischio, J. (2019). IgG4 Inflammatory Disease Presenting as Retro-orbital Mass. JCR: Journal of Clinical Rheumatology, 1.


Lewis, C. G., & Blaine, T. A. (2020). Co-management Agreements Prove to be Viable Models for Physician Input. April 2019, 1–7.


Magaldi, R. J., Staff, I., Stovall, A. E., Stohler, S. A., & Lewis, C. G. (2019). Impact of Resilience on Outcomes of Total Knee Arthroplasty. Journal of Arthroplasty, 34(11), 2620-2623.e1.


Maier, F., Lewis, C. G., & Pierce, D. M. (2019). The evolving large-strain shear responses of progressively osteoarthritic human cartilage. Osteoarthritis and Cartilage, 27(5), 810–822.


Maier, F., Lewis, C. G., & Pierce, D. M. (2019). Through-thickness patterns of shear strain evolve in early osteoarthritis. Osteoarthritis and Cartilage, 27(9), 1382–1391.


MARS Group, Bigouette, J. P., Owen, E. C., Lantz, B. B. A., Hoellrich, R. G., Huston, L. J., Haas, A. K., Allen, C. R., Anderson, A. F., Cooper, D. E., DeBerardino, T. M., Dunn, W. R., Mann, B., Spindler, K. P., Stuart, M. J., Wright, R. W., Albright, J. P., Amendola, A. N., Andrish, J. T.,… York, J. J. (2019). Relationship Between Sports Participation After Revision Anterior Cruciate Ligament Reconstruction and 2-Year Patient-Reported Outcome Measures. The American Journal of Sports Medicine, 47(9), 2056–2066.


Nissen, C. W. (2019). Arm Issues in Young Throwers: Why are They Increasing? Connecticut Medicine, 83(9), 453–457.


Solomito, M. J., Garibay, E. J., & Nissen, C. W. (2019). Deceleration phase elbow varus moments: a potential injury mechanism for collegiate baseball pitchers. Sports Biomechanics.


Szolomayer, L. K., Kuether, J., Kassam, H. F., Mata Fink, A., Regnell, E., Kovacevic, D., & Blaine, T. A. (2019). Outcomes of Total Shoulder Arthroplasty With Posterior Capsular Plication. Journal of Shoulder and Elbow Arthroplasty, 3, 247154921882238.


Tong, K., Nolan, W., O’Sullivan, D. M., Sheiner, P., & Kutzler, H. L. (2019). Implementation of a Multimodal Pain Management Order Set Reduces Perioperative Opioid Use after Liver Transplantation. Pharmacotherapy, 39(10), 975–982.


Current Research Topics

ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee

PI: Carl W. Nissen, MD

Multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shoulders

PI: Jennifer A. Sposito, MD

Single-center, prospective, randomized controlled cross-sectional study comparing interscalene brachial plexus block with liposomal bupivacaine versus bupivacaine with epinephrine and PF dexamethasone in patients undergoing primary shoulder arthroplasty. Primary endpoint will be total opioid consumption in the first three post-operative days.

A Phase 2B, Prospective, Double-blinded, Randomized Controlled Trial of the Micronized Dehydrated Human Amnion Chorion Membrane Injection as Compared to Saline Placebo Injection in the Treatment of Osteoarthritis of the Knee

PI: Carl W. Nissen, MD

The purpose of this study is to determine the safety and effectiveness of micronized dehydrated human amnion chorion membrane as compared to the 0.9% Sodium Chloride Injection, USP placebo control for the treatment of knee osteoarthritis


PI: Carl W. Nissen, MD

Centralized, comprehensive database of elbow OCD cases to act as a platform for future studies on OCD, providing the institutions that are part of ROCK (Research in OsteoChondritis of the Knee) with a large database including the different types of elbow OCD lesions and variables associated with the disease characteristics, course of treatment and healing, and long term follow up.

The Characterization of the Upper Extremity Biomechanics during the Lacrosse Face Off

PI: Carl W. Nissen, MD

In this prospective descriptive study we will describe the kinematics and kinetics involved with the lacrosse faceoff to better understand the related injury risks. We hypothesize that the lacrosse faceoff places significant stress on the player and specifically on the athlete’s shoulder. 

Functional Outcome Comparison of Elliptical and Spherical Head Shoulder Arthroplasty Utilizing Biomechanical 3D Video Motion Analysis

PI: Theodore Blaine, MD

The purpose of this study is to understand patient outcomes and improve clinically relevant evaluation of patients undergoing total shoulder arthroplasty (TSA). Our purpose is to describe the clinical results for the elliptical and spherical humeral heads used in TSA. This study will provide range-of-motion measurements measured both clinically and with modern 3D motion analysis as the gold standard.  Additionally we will obtain the functional status of these patients in basic ADLs

Retrospective/Other Studies

Capitellar X-ray Reliability Study for Osteochondritis Dissecans of Elbow

PI: Carl W. Nissen, MD

How often does fever after orthopedic surgery correlate with an infectious process and how to identify patients warranting focused work ups?

PI: Mandeep Kumar, MD

Identifying variables and outcomes associated with anemia and blood transfusions in hip fracture patients 

PI: Mandeep Kumar, MD

Clinical Outcomes of Inflammatory Disc Disease Compared to Other Degenerative Disc Etiologies: A Retrospective Study

PI: Mandeep Kumar, MD

Arthroscopic-Assisted Suprapectoral Krakow (ASK) Biceps Tenodesis Retrospective Review

PI: Theodore Blaine, MD

The Role of Beef in Optimal Protein and Feeding Strategies to Accelerate Muscle Mass and Functional Recovery From Anterior Cruciate Ligament (ACL) Repair

PI: Nancy Rodriguez, PhD

Efficacy and safety of topical tranexamic acid in hip fracture patients; a retrospective review

PI: Daniel Witmer, MD

Research at Bone & Joint Institute





Hartford Hospital

Bone & Joint Institute

The Bone & Joint Institute at Hartford Hospital is a multidisciplinary group of providers united by the common goal to deliver world class comprehensive musculoskeletal care.

About Bone & Joint Institute